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Activation and inhibition of proteasomes by betulinic acid and its derivatives

This study discovered that betulinic acid (BA) is a potent proteasome activator that preferentially activates the chymotrypsin-like activity of proteasomes. Chemical modifications can transform BA into proteasome inhibitors. Chemical modifications at the C-3 position of BA resulted in compounds, suc...

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Sonraí Bibleagrafaíochta
Main Authors: Huang, Li, Ho, Phong, Chen, Chin-Ho
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2083647/
https://ncbi.nlm.nih.gov/pubmed/17904555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.09.031
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