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Activation and inhibition of proteasomes by betulinic acid and its derivatives
This study discovered that betulinic acid (BA) is a potent proteasome activator that preferentially activates the chymotrypsin-like activity of proteasomes. Chemical modifications can transform BA into proteasome inhibitors. Chemical modifications at the C-3 position of BA resulted in compounds, suc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2083647/ https://ncbi.nlm.nih.gov/pubmed/17904555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.09.031 |
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