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New Betulinic Acid Derivatives as Potent Proteasome Inhibitors
In this study, 22 new betulinic acid (BA) derivatives were synthesized and tested for their inhibition of the chymotrypsin-like activity of 20S proteasome. From the SAR study, we concluded that the C-3 and C-30 positions are the pharmacophores for increasing the proteasome inhibition effects, and la...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3171619/ https://ncbi.nlm.nih.gov/pubmed/21856154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.07.072 |
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