A carregar...
Design, synthesis, and structure activity relationship analysis of new betulinic acid derivatives as potent HIV inhibitors
Prior modification of betulinic acid (1), a natural product lead with promising anti-HIV activity, produced 3-O-(3′,3′-dimethylsuccinyl)betulinic acid (bevirimat, 3), the first-in-class HIV maturation inhibitor. After 3-resistant variants were found during Phase I and IIa clinical trials, further mo...
Na minha lista:
| Publicado no: | Eur J Med Chem |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8176629/ https://ncbi.nlm.nih.gov/pubmed/33639343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2021.113287 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|