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Synthesis and Proteasome Inhibition of Glycyrrhetinic Acid Derivatives
This study discovered that glycyrrhetinic acid inhibited the human 20S proteasome at 22.3 µM. Esterification of the C-3 hydroxyl group on glycyrrhetinic acid with various carboxylic acid reagents yielded a series of analogs with marked improved potency. Among the derivatives, glycyrrhetinic acid 3-O...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2579312/ https://ncbi.nlm.nih.gov/pubmed/18562200 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.05.078 |
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