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Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators

[Image: see text] Accumulation of aberrant protein aggregates, such as amyloid β peptide (Aβ), due to decreased proteasome activities, might contribute to the neurodegeneration in Alzheimer's disease. In this study, lithocholic acid derivatives 3α-O-pimeloyl-lithocholic acid methyl ester (2) an...

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Detalhes bibliográficos
Main Authors: Dang, Zhao, Jung, Kathy, Qian, Keduo, Lee, Kuo-Hsiung, Huang, Li, Chen, Chin-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3544189/
https://ncbi.nlm.nih.gov/pubmed/23330053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3001962
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