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Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators
[Image: see text] Accumulation of aberrant protein aggregates, such as amyloid β peptide (Aβ), due to decreased proteasome activities, might contribute to the neurodegeneration in Alzheimer's disease. In this study, lithocholic acid derivatives 3α-O-pimeloyl-lithocholic acid methyl ester (2) an...
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Main Authors: | , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American
Chemical Society
2012
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3544189/ https://ncbi.nlm.nih.gov/pubmed/23330053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3001962 |
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