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Prion Protein Expression Differences in Microglia and Astroglia Influence Scrapie-Induced Neurodegeneration in the Retina and Brain of Transgenic Mice

Activated microglia and astroglia are known to be involved in a variety of neurodegenerative diseases, including prion diseases. In the present experiments, we studied activation of astroglia and microglia after intraocular scrapie infection in transgenic mice expressing prion protein (PrP) in multi...

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Detalhes bibliográficos
Main Authors: Kercher, Lisa, Favara, Cynthia, Striebel, James F., LaCasse, Rachel, Chesebro, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045503/
https://ncbi.nlm.nih.gov/pubmed/17652390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00865-07
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