Strain Specific Resistance to Murine Scrapie Associated with a Naturally Occurring Human Prion Protein Polymorphism at Residue 171

Transmissible spongiform encephalopathies (TSE) or prion diseases are neurodegenerative disorders associated with conversion of normal host prion protein (PrP) to a misfolded, protease-resistant form (PrPres). Genetic variations of prion protein in humans and animals can alter susceptibility to both...

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Hauptverfasser: Striebel, James F., Race, Brent, Meade-White, Kimberly D., LaCasse, Rachel, Chesebro, Bruce
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182929/
https://ncbi.nlm.nih.gov/pubmed/21980292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002275
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