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Role of Erk1/2 Activation in Prion Disease Pathogenesis: Absence of CCR1 Leads to Increased Erk1/2 Activation and Accelerated Disease Progression
Prion diseases are neurodegenerative infections with gliosis and vacuolation. The mechanisms of degeneration remain unclear, but chemokines may be important. In current experiments CCR1 knock-out (KO) mice succumbed more rapidly to scrapie infection than WT controls. Infected KO mice had upregulatio...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2532820/ https://ncbi.nlm.nih.gov/pubmed/18396336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2008.02.009 |
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