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Role of Erk1/2 Activation in Prion Disease Pathogenesis: Absence of CCR1 Leads to Increased Erk1/2 Activation and Accelerated Disease Progression

Prion diseases are neurodegenerative infections with gliosis and vacuolation. The mechanisms of degeneration remain unclear, but chemokines may be important. In current experiments CCR1 knock-out (KO) mice succumbed more rapidly to scrapie infection than WT controls. Infected KO mice had upregulatio...

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Detalhes bibliográficos
Main Authors: LaCasse, Rachel A., Striebel, James F., Favara, Cynthia, Kercher, Lisa, Chesebro, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532820/
https://ncbi.nlm.nih.gov/pubmed/18396336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2008.02.009
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