Familial Alzheimer's disease mutations alter the stability of the amyloid β-protein monomer folding nucleus

Amyloid β-protein (Aβ) oligomers may be the proximate neurotoxins in Alzheimer's disease (AD). Recently, to elucidate the oligomerization pathway, we studied Aβ monomer folding and identified a decapeptide segment of Aβ, (21)Ala–(22)Glu–(23)Asp–(24)Val–(25)Gly–(26)Ser–(27)Asn–(28)Lys–(29)Gly–(3...

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Autori principali: Grant, Marianne A., Lazo, Noel D., Lomakin, Aleksey, Condron, Margaret M., Arai, Hiromi, Yamin, Ghiam, Rigby, Alan C., Teplow, David B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034231/
https://ncbi.nlm.nih.gov/pubmed/17940047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705197104
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