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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

The inactivation of the von Hippel-Lindau (VHL) gene predisposes affected individuals to VHL syndrome and is an early genetic event associated with sporadic renal cell carcinoma and CNS hemangioblastomas. The VHL protein (pVHL) has been shown to form a stable complex with elongin B and elongin C, tw...

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Detalhes bibliográficos
Main Authors: Pause, Arnim, Lee, Stephen, Worrell, Robert A., Chen, David Y. T., Burgess, Wilson H., Linehan, W. Marston, Klausner, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC20057/
https://ncbi.nlm.nih.gov/pubmed/9122164
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