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The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

The inactivation of the von Hippel-Lindau (VHL) gene predisposes affected individuals to VHL syndrome and is an early genetic event associated with sporadic renal cell carcinoma and CNS hemangioblastomas. The VHL protein (pVHL) has been shown to form a stable complex with elongin B and elongin C, tw...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Pause, Arnim, Lee, Stephen, Worrell, Robert A., Chen, David Y. T., Burgess, Wilson H., Linehan, W. Marston, Klausner, Richard D.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20057/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122164/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2156
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