The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

The inactivation of the von Hippel-Lindau (VHL) gene predisposes affected individuals to VHL syndrome and is an early genetic event associated with sporadic renal cell carcinoma and CNS hemangioblastomas. The VHL protein (pVHL) has been shown to form a stable complex with elongin B and elongin C, tw...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pause, Arnim, Lee, Stephen, Worrell, Robert A., Chen, David Y. T., Burgess, Wilson H., Linehan, W. Marston, Klausner, Richard D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20057/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122164/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2156
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