The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

The inactivation of the von Hippel-Lindau (VHL) gene predisposes affected individuals to VHL syndrome and is an early genetic event associated with sporadic renal cell carcinoma and CNS hemangioblastomas. The VHL protein (pVHL) has been shown to form a stable complex with elongin B and elongin C, tw...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Pause, Arnim, Lee, Stephen, Worrell, Robert A., Chen, David Y. T., Burgess, Wilson H., Linehan, W. Marston, Klausner, Richard D.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1997
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20057/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122164/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2156
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