Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

Mutations of von Hippel–Lindau disease (VHL) tumor-suppressor gene product (pVHL) are found in patients with dominant inherited VHL syndrome and in the vast majority of sporadic clear cell renal carcinomas. The function of the pVHL protein has not been clarified. pVHL has been shown to form a comple...

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Bibliographic Details
Main Authors: Iwai, Kazuhiro, Yamanaka, Koji, Kamura, Takumi, Minato, Nagahiro, Conaway, Ronald C., Conaway, Joan W., Klausner, Richard D., Pause, Arnim
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC22941/
https://ncbi.nlm.nih.gov/pubmed/10535940
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