Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

Mutations of von Hippel–Lindau disease (VHL) tumor-suppressor gene product (pVHL) are found in patients with dominant inherited VHL syndrome and in the vast majority of sporadic clear cell renal carcinomas. The function of the pVHL protein has not been clarified. pVHL has been shown to form a comple...

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Hlavní autoři: Iwai, Kazuhiro, Yamanaka, Koji, Kamura, Takumi, Minato, Nagahiro, Conaway, Ronald C., Conaway, Joan W., Klausner, Richard D., Pause, Arnim
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1999
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC22941/
https://ncbi.nlm.nih.gov/pubmed/10535940
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