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The von Hippel–Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

The inactivation of the von Hippel–Lindau (VHL) tumor suppressor gene predisposes affected individuals to the human VHL cancer syndrome and is associated with sporadic renal cell carcinomas (RCC) and brain hemangioblastomas. VHL-negative 786–0 RCC cells are tumorigenic in nude mice which is suppress...

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Detalhes bibliográficos
Main Authors: Pause, Arnim, Lee, Stephen, Lonergan, Kim M., Klausner, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC18649/
https://ncbi.nlm.nih.gov/pubmed/9448273
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