The von Hippel–Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

The inactivation of the von Hippel–Lindau (VHL) tumor suppressor gene predisposes affected individuals to the human VHL cancer syndrome and is associated with sporadic renal cell carcinomas (RCC) and brain hemangioblastomas. VHL-negative 786–0 RCC cells are tumorigenic in nude mice which is suppress...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Pause, Arnim, Lee, Stephen, Lonergan, Kim M., Klausner, Richard D.
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1998
Subjects:	Biological Sciences
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC18649/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9448273/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.3.993
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