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Induction of BIM Is Essential for Apoptosis Triggered by EGFR Kinase Inhibitors in Mutant EGFR-Dependent Lung Adenocarcinomas

BACKGROUND: Mutations in the epidermal growth factor receptor (EGFR) gene are associated with increased sensitivity of lung cancers to kinase inhibitors like erlotinib. Mechanisms of cell death that occur after kinase inhibition in these oncogene-dependent tumors have not been well delineated. We so...

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Detalhes bibliográficos
Main Authors: Gong, Yixuan, Somwar, Romel, Politi, Katerina, Balak, Marissa, Chmielecki, Juliann, Jiang, Xuejun, Pao, William
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2001209/
https://ncbi.nlm.nih.gov/pubmed/17927446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0040294
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