Development of New Mouse Lung Tumor Models Expressing EGFR T790M Mutants Associated with Clinical Resistance to Kinase Inhibitors

BACKGROUND: The EGFR T790M mutation confers acquired resistance to kinase inhibitors in human EGFR mutant lung adenocarcinoma, is occasionally detected before treatment, and may confer genetic susceptibility to lung cancer. METHODOLOGY/PRINCIPAL FINDINGS: To study further its role in lung tumorigene...

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Huvudupphovsmän: Regales, Lucia, Balak, Marissa N., Gong, Yixuan, Politi, Katerina, Sawai, Ayana, Le, Carl, Koutcher, Jason A., Solit, David B., Rosen, Neal, Zakowski, Maureen F., Pao, William
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2007
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1950079/
https://ncbi.nlm.nih.gov/pubmed/17726540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000810
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