Induction of BIM Is Essential for Apoptosis Triggered by EGFR Kinase Inhibitors in Mutant EGFR-Dependent Lung Adenocarcinomas

BACKGROUND: Mutations in the epidermal growth factor receptor (EGFR) gene are associated with increased sensitivity of lung cancers to kinase inhibitors like erlotinib. Mechanisms of cell death that occur after kinase inhibition in these oncogene-dependent tumors have not been well delineated. We so...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Gong, Yixuan, Somwar, Romel, Politi, Katerina, Balak, Marissa, Chmielecki, Juliann, Jiang, Xuejun, Pao, William
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2007
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2001209/
https://ncbi.nlm.nih.gov/pubmed/17927446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0040294
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