SPATIAL AND FUNCTIONAL RELATIONSHIP BETWEEN POLY(ADP-RIBOSE) POLYMERASE-1 AND POLY(ADP-RIBOSE) GLYCOHYDROLASE IN THE BRAIN

Poly(ADP-ribose) polymerases (PARPs) are members of a family of enzymes that utilize NAD(+) as substrate to form large ADP-ribose polymers (PAR) in the nucleus. PAR has a very short half life due to its rapid degradation by poly(ADP-ribose) glycohydrolase (PARG). PARP-1 mediates acute neuronal cell...

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Main Authors: Poitras, Marc F., Koh, David W., Yu, Seong-Woon, Andrabi, Shaida A., Mandir, Allen S., Poirier, Guy G., Dawson, Valina L., Dawson, Ted M.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000859/
https://ncbi.nlm.nih.gov/pubmed/17640816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2007.04.062
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