Poly(ADP-ribose) (PAR) polymer is a death signal

Excessive activation of the nuclear enzyme, poly(ADP-ribose) polymerase-1 (PARP-1) plays a prominent role in various of models of cellular injury. Here, we identify poly(ADP-ribose) (PAR) polymer, a product of PARP-1 activity, as a previously uncharacterized cell death signal. PAR polymer is directl...

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Detalhes bibliográficos
Main Authors: Andrabi, Shaida A., Kim, No Soo, Yu, Seong-Woon, Wang, Hongmin, Koh, David W., Sasaki, Masayuki, Klaus, Judith A., Otsuka, Takashi, Zhang, Zhizheng, Koehler, Raymond C., Hurn, Patricia D., Poirier, Guy G., Dawson, Valina L., Dawson, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1838747/
https://ncbi.nlm.nih.gov/pubmed/17116882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606526103
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