Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality

The metabolism of poly(ADP-ribose) (PAR) is critical for genomic stability in multicellular eukaryotes. Here, we show that the failure to degrade PAR by means of disruption of the murine poly(ADP-ribose) glycohydrolase (PARG) gene unexpectedly causes early embryonic lethality and enhanced sensitivit...

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Detalhes bibliográficos
Main Authors: Koh, David W., Lawler, Ann M., Poitras, Marc F., Sasaki, Masayuki, Wattler, Sigrid, Nehls, Michael C., Stöger, Tobias, Poirier, Guy G., Dawson, Valina L., Dawson, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC539714/
https://ncbi.nlm.nih.gov/pubmed/15591342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406182101
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