NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase

Poly(ADP-ribose) polymerase (PARP-1), a nuclear enzyme that facilitates DNA repair, may be instrumental in acute neuronal cell death in a variety of insults including, cerebral ischemia,1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism, and CNS trauma. Excitotoxicity is thought to un...

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Publicat a:J Neurosci
Autors principals: Mandir, Allen S., Poitras, Marc F., Berliner, Adam R., Herring, William J., Guastella, Daniel B., Feldman, Alicia, Poirier, Guy G., Wang, Zhao-Qi, Dawson, Ted M., Dawson, Valina L.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2000
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ARTICLE
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772735/
https://ncbi.nlm.nih.gov/pubmed/11050121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-21-08005.2000
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