Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that causes parkinsonism in humans and nonhuman animals, and its use has led to greater understanding of the pathogenesis of Parkinson’s disease. However, its molecular targets have not been defined. We show that mice lacking the ge...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Mandir, Allen S., Przedborski, Serge, Jackson-Lewis, Vernice, Wang, Zhao-Qi, Simbulan-Rosenthal, Cynthia M., Smulson, Mark E., Hoffman, Brian E., Guastella, Daniel B., Dawson, Valina L., Dawson, Ted M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1999
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21936/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10318960/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.10.5774
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