Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that causes parkinsonism in humans and nonhuman animals, and its use has led to greater understanding of the pathogenesis of Parkinson’s disease. However, its molecular targets have not been defined. We show that mice lacking the ge...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Mandir, Allen S., Przedborski, Serge, Jackson-Lewis, Vernice, Wang, Zhao-Qi, Simbulan-Rosenthal, Cynthia M., Smulson, Mark E., Hoffman, Brian E., Guastella, Daniel B., Dawson, Valina L., Dawson, Ted M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 1999
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC21936/
https://ncbi.nlm.nih.gov/pubmed/10318960
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