Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin that causes parkinsonism in humans and nonhuman animals, and its use has led to greater understanding of the pathogenesis of Parkinson’s disease. However, its molecular targets have not been defined. We show that mice lacking the ge...

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發表在:	Proc Natl Acad Sci U S A
Principais autores:	Mandir, Allen S., Przedborski, Serge, Jackson-Lewis, Vernice, Wang, Zhao-Qi, Simbulan-Rosenthal, Cynthia M., Smulson, Mark E., Hoffman, Brian E., Guastella, Daniel B., Dawson, Valina L., Dawson, Ted M.
格式:	Artigo
語言:	Inglês
出版:	National Academy of Sciences 1999
主題:	Biological Sciences
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21936/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10318960/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.10.5774
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