Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

The decrement in dopamine levels exceeds the loss of dopaminergic neurons in Parkinson’s disease (PD) patients and experimental models of PD. This discrepancy is poorly understood and may represent an important event in the pathogenesis of PD. Herein, we report that the rate-limiting enzyme in dopam...

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Foilsithe in:	Proc Natl Acad Sci U S A
Príomhchruthaitheoirí:	Ara, Jahan, Przedborski, Serge, Naini, Ali B., Jackson-Lewis, Vernice, Trifiletti, Rosario R., Horwitz, Joel, Ischiropoulos, Harry
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	National Academy of Sciences 1998
Ábhair:	Biological Sciences
Rochtain ar líne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22714/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9636206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.13.7659
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