Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

The decrement in dopamine levels exceeds the loss of dopaminergic neurons in Parkinson’s disease (PD) patients and experimental models of PD. This discrepancy is poorly understood and may represent an important event in the pathogenesis of PD. Herein, we report that the rate-limiting enzyme in dopam...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ara, Jahan, Przedborski, Serge, Naini, Ali B., Jackson-Lewis, Vernice, Trifiletti, Rosario R., Horwitz, Joel, Ischiropoulos, Harry
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22714/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9636206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.13.7659
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