Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) damages dopaminergic neurons in the substantia nigra pars compacta (SNpc) as seen in Parkinson's disease. Here, we show that the pro-apoptotic protein Bax is highly expressed in the SNpc and that its ablation attenuates SNpc developmental neur...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Vila, Miquel, Jackson-Lewis, Vernice, Vukosavic, Slobodanka, Djaldetti, Ruth, Liberatore, Gabriel, Offen, Daniel, Korsmeyer, Stanley J., Przedborski, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC30226/
https://ncbi.nlm.nih.gov/pubmed/11226327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051633998
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados