Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) damages dopaminergic neurons in the substantia nigra pars compacta (SNpc) as seen in Parkinson's disease. Here, we show that the pro-apoptotic protein Bax is highly expressed in the SNpc and that its ablation attenuates SNpc developmental neur...

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Detaylı Bibliyografya
Asıl Yazarlar: Vila, Miquel, Jackson-Lewis, Vernice, Vukosavic, Slobodanka, Djaldetti, Ruth, Liberatore, Gabriel, Offen, Daniel, Korsmeyer, Stanley J., Przedborski, Serge
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2001
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC30226/
https://ncbi.nlm.nih.gov/pubmed/11226327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051633998
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