LRRK2 G2019S Transgenic Mice Display Increased Susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-Mediated Neurotoxicity

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common causes of late onset autosomal dominant form of Parkinson disease (PD). Gain of kinase activity due to the substitution of Gly 2019 to Ser (G2019S) is the most common mutation in the kinase domain of LRRK2. Genetic predisposition...

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Publicado no:J Chem Neuroanat
Main Authors: Karuppagounder, Senthilkumar S., Xiong, Yulan, Lee, Yunjong, Lawless, Maeve C., Kim, Donghyun, Nordquist, Emily, Martin, Ian, Ge, Preston, Brahmachari, Saurav, Jhaldiyal, Aanishaa, kumar, Manoj, Andrabi, Shaida A., Dawson, Ted M., Dawson, Valina L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4958044/
https://ncbi.nlm.nih.gov/pubmed/26808467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchemneu.2016.01.007
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