Poly(ADP-ribose) polymerase-dependent energy depletion occurs through inhibition of glycolysis

Excessive poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation kills cells via a cell-death process designated “parthanatos” in which PAR induces the mitochondrial release and nuclear translocation of apoptosis-inducing factor to initiate chromatinolysis and cell death. Accompanying the formation...

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Detalhes bibliográficos
Main Authors: Andrabi, Shaida A., Umanah, George K. E., Chang, Calvin, Stevens, Daniel A., Karuppagounder, Senthilkumar S., Gagné, Jean-Philippe, Poirier, Guy G., Dawson, Valina L., Dawson, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104885/
https://ncbi.nlm.nih.gov/pubmed/24987120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1405158111
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