Poly (ADP-ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical For PAR Polymerase-1-Dependent Cell Death (Parthanatos)

The mitochondrial protein apoptosis-inducing factor (AIF) plays a pivotal role in poly(ADP-ribose) polymerase-1 (PARP-1)-mediated cell death (parthanatos), during which it is released from the mitochondria and translocates to the nucleus. Here, we show that AIF is a high affinity poly(ADP-ribose) (P...

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Hauptverfasser: Wang, Yingfei, Kim, No Soo, Haince, Jean-Francois, Kang, HoChul, David, Karen K., Andrabi, Shaida A., Poirier, Guy G., Dawson, Valina L., Dawson, Ted M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3086524/
https://ncbi.nlm.nih.gov/pubmed/21467298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000902
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