Synthesis and biological evaluation of (−)-dictyostatin and stereoisomers

Total syntheses of (−)-dictyostatin, 6,16-bis-epi-dictyostatin, 6,14,19-tris-epi-dictyostatin and a number of other isomers and analogs are reported. Three main fragments—top, middle and bottom—were first assembled and then joined by olefination or anionic addition reactions. After appending the two...

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Main Authors: Shin, Youseung, Fournier, Jean-Hugues, Brückner, Arndt, Madiraju, Charitha, Balachandran, Raghavan, Raccor, Brianne S., Edler, Michael C., Hamel, Ernest, Sikorski, Rachel P., Vogt, Andreas, Day, Billy W., Curran, Dennis P.
Format: Artigo
Jezik:Inglês
Izdano: 2007
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2000856/
https://ncbi.nlm.nih.gov/pubmed/18728696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2007.05.033
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