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High-content analysis of cancer-cell specific apoptosis and inhibition of in vivo angiogenesis by synthetic (−)-pironetin and analogs
The natural product (−)-pironetin is a structurally simple small molecule microtubule (MT) perturbing agent whose biological activities appear to be exquisitely dependent on defined stereochemistry and the presence of an eletrophilic α,β-unsaturated lactone moiety. We used alkaloid-catalyzed acyl ha...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963022/ https://ncbi.nlm.nih.gov/pubmed/19691472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2009.00866.x |
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