High-content analysis of cancer-cell specific apoptosis and inhibition of in vivo angiogenesis by synthetic (−)-pironetin and analogs

The natural product (−)-pironetin is a structurally simple small molecule microtubule (MT) perturbing agent whose biological activities appear to be exquisitely dependent on defined stereochemistry and the presence of an eletrophilic α,β-unsaturated lactone moiety. We used alkaloid-catalyzed acyl ha...

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Hoofdauteurs: Vogt, Andreas, McPherson, Peter A., Shen, Xiaoqiang, Balachandran, Raghavan, Zhu, Guangyu, Raccor, Brianne S., Nelson, Scott G., Tsang, Michael, Day, Billy W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963022/
https://ncbi.nlm.nih.gov/pubmed/19691472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2009.00866.x
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