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Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts

Structure-activity studies centered on the naturally occurring antitumor agent dictyostatin have recently identified several highly active epimers and analogs. From these compounds, 6-epi-dictyostatin was selected for scaleup preparation and evaluation in animals. Here we describe a new total synthe...

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Detalhes bibliográficos
Main Authors: Eiseman, Julie L., Bai, Lihua, Jung, Won-Hyuk, Moura-Letts, Gustavo, Day, Billy W., Curran, Dennis P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2627582/
https://ncbi.nlm.nih.gov/pubmed/18839939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm800979v
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