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Streamlined syntheses of (−)-dictyostatin, 25,26-dihydro-16-desmethyldictyostatin, and 6-epi-25,26-dihydro-16-desmethyldictyostatin

The dictyostatins are a promising class of potential anticancer drugs because they are powerful microtubule stabilizing agents, but the complexity of their chemical structures is a severe impediment to their further development. Based on both synthetic and medicinal chemistry analyses, 25,26-dihydro...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Wei, Jiménez, María, Jung, Won-Hyuk, Camarco, Daniel P., Balachandran, Raghavan, Vogt, Andreas, Day, Billy W., Curran, Dennis P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2903049/
https://ncbi.nlm.nih.gov/pubmed/20545347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja103537u
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