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Rational design of a triple helix-specific intercalating ligand

DNA triple helices offer new perspectives toward oligonucleotide-directed gene regulation. However, the poor stability of some of these structures might limit their use under physiological conditions. Specific ligands can intercalate into DNA triple helices and stabilize them. Molecular modeling and...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Escudé, Christophe, Nguyen, Chi Hung, Kukreti, Shrikant, Janin, Yves, Sun, Jian-Sheng, Bisagni, Emile, Garestier, Thérèse, Hélène, Claude
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1998
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19880/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9520410/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.7.3591
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