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Rational design of a triple helix-specific intercalating ligand

DNA triple helices offer new perspectives toward oligonucleotide-directed gene regulation. However, the poor stability of some of these structures might limit their use under physiological conditions. Specific ligands can intercalate into DNA triple helices and stabilize them. Molecular modeling and...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Escudé, Christophe, Nguyen, Chi Hung, Kukreti, Shrikant, Janin, Yves, Sun, Jian-Sheng, Bisagni, Emile, Garestier, Thérèse, Hélène, Claude
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19880/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9520410/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.7.3591
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