Rational design of a triple helix-specific intercalating ligand

DNA triple helices offer new perspectives toward oligonucleotide-directed gene regulation. However, the poor stability of some of these structures might limit their use under physiological conditions. Specific ligands can intercalate into DNA triple helices and stabilize them. Molecular modeling and...

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Autors principals: Escudé, Christophe, Nguyen, Chi Hung, Kukreti, Shrikant, Janin, Yves, Sun, Jian-Sheng, Bisagni, Emile, Garestier, Thérèse, Hélène, Claude
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1998
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC19880/
https://ncbi.nlm.nih.gov/pubmed/9520410
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