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Rational design of a triple helix-specific intercalating ligand

DNA triple helices offer new perspectives toward oligonucleotide-directed gene regulation. However, the poor stability of some of these structures might limit their use under physiological conditions. Specific ligands can intercalate into DNA triple helices and stabilize them. Molecular modeling and...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Escudé, Christophe, Nguyen, Chi Hung, Kukreti, Shrikant, Janin, Yves, Sun, Jian-Sheng, Bisagni, Emile, Garestier, Thérèse, Hélène, Claude
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19880/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9520410/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.7.3591
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