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Rational design of a triple helix-specific intercalating ligand

DNA triple helices offer new perspectives toward oligonucleotide-directed gene regulation. However, the poor stability of some of these structures might limit their use under physiological conditions. Specific ligands can intercalate into DNA triple helices and stabilize them. Molecular modeling and...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Escudé, Christophe, Nguyen, Chi Hung, Kukreti, Shrikant, Janin, Yves, Sun, Jian-Sheng, Bisagni, Emile, Garestier, Thérèse, Hélène, Claude
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 1998
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Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19880/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9520410/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.7.3591
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