Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells

Capped RNAs synthesized by in vitro transcription have found wide utility for studying mRNA function and metabolism and for producing proteins of interest. We characterize here a recently synthesized series of cap analogs with improved properties that contain a sulfur substitution for a nonbridging...

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Hlavní autoři: Grudzien-Nogalska, Ewa, Jemielity, Jacek, Kowalska, Joanna, Darzynkiewicz, Edward, Rhoads, Robert E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1986804/
https://ncbi.nlm.nih.gov/pubmed/17720878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.701307
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