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Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH(3), Se, and NH

Decapping is an essential step in multiple pathways of mRNA degradation. Previously, we synthesized mRNAs containing caps that were resistant to decapping, both to dissect the various pathways for mRNA degradation and to stabilize mRNA for more sustained protein expression. mRNAs containing an α-β C...

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Bibliografske podrobnosti
Main Authors: Su, Wei, Slepenkov, Sergey, Grudzien-Nogalska, Ewa, Kowalska, Joanna, Kulis, Marta, Zuberek, Joanna, Lukaszewicz, Maciej, Darzynkiewicz, Edward, Jemielity, Jacek, Rhoads, Robert E.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078746/
https://ncbi.nlm.nih.gov/pubmed/21447710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2430711
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