Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH(3), Se, and NH

Decapping is an essential step in multiple pathways of mRNA degradation. Previously, we synthesized mRNAs containing caps that were resistant to decapping, both to dissect the various pathways for mRNA degradation and to stabilize mRNA for more sustained protein expression. mRNAs containing an α-β C...

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Detalhes bibliográficos
Main Authors: Su, Wei, Slepenkov, Sergey, Grudzien-Nogalska, Ewa, Kowalska, Joanna, Kulis, Marta, Zuberek, Joanna, Lukaszewicz, Maciej, Darzynkiewicz, Edward, Jemielity, Jacek, Rhoads, Robert E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2011
Assuntos:
Method
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078746/
https://ncbi.nlm.nih.gov/pubmed/21447710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.2430711
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