Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

Along with a growing interest in mRNA-based gene therapies, efforts are increasingly focused on reaching the full translational potential of mRNA, as a major obstacle for in vivo applications is sufficient expression of exogenously delivered mRNA. One method to overcome this limitation is chemically...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Principais autores: Strenkowska, Malwina, Grzela, Renata, Majewski, Maciej, Wnek, Katarzyna, Kowalska, Joanna, Lukaszewicz, Maciej, Zuberek, Joanna, Darzynkiewicz, Edward, Kuhn, Andreas N., Sahin, Ugur, Jemielity, Jacek
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5175369/
https://ncbi.nlm.nih.gov/pubmed/27903882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw896
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