Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications†,

We describe the chemical synthesis and preliminary biophysical and biochemical characterization of a series of mRNA 5' end (cap) analogs designed as reagents for obtaining mRNA molecules with augmented translation efficiency and stability in vivo and as useful tools to study mRNA metabolism. Th...

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Main Authors: Strenkowska, Malwina, Kowalska, Joanna, Lukaszewicz, Maciej, Zuberek, Joanna, Su, Wei, Rhoads, Robert E., Darzynkiewicz, Edward, Jemielity, Jacek
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918917/
https://ncbi.nlm.nih.gov/pubmed/20711517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b9nj00644c
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