Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications†,

We describe the chemical synthesis and preliminary biophysical and biochemical characterization of a series of mRNA 5' end (cap) analogs designed as reagents for obtaining mRNA molecules with augmented translation efficiency and stability in vivo and as useful tools to study mRNA metabolism. Th...

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Hauptverfasser: Strenkowska, Malwina, Kowalska, Joanna, Lukaszewicz, Maciej, Zuberek, Joanna, Su, Wei, Rhoads, Robert E., Darzynkiewicz, Edward, Jemielity, Jacek
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918917/
https://ncbi.nlm.nih.gov/pubmed/20711517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b9nj00644c
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